Bioinformatics Research Group

Congratulations to our former intern, Gabriel Flores!
He won that award for his presentation of our work on 'Machine learning-based prediction of coil conversion to β-strand in dimer formation'.
SINAPSIS is the anual meeting of Peruvian scientists in Europe.

In Silico Design of Bioisosteric Modifications of a Drug for the Treatment of Diabetes:
- Guillaume Vink (speaker)
- Stephen Wren (supervisor)
- Gabriel Flores Lipa
Previous seminars

Congratulations to Johanna Laibe, MSc by Research student!
In between the (beta) sheets

The main goal of CASP (Critical Assessment of protein Structure Prediction) is to obtain an in-depth and objective assessment of our current abilities and inabilities in the area of protein structure prediction.

CAPRI (Critical Assessment of PRediction of Interactions) is the communitywide experiment on the comparative evaluation of protein-protein docking for structure prediction.

J.-C. Nebel was invited speaker at the 11th Workshop on Bioinformatics and 6th Symposium of the Polish Bioinformatics Society, 27-29 September 2013, Wroclaw, Poland

(Structural analysis) since 2016

Kingston University and Nice Sophia Antipolis University, publications [*]

Prediction whether a monomer has the potential to form a dimer through the conversion of one of its coils into a beta strand to form a beta sheet portein-protein interface.

Kingston University and Lebanese-American University, publications [*]

Kingston University, publications [*]

Kingston University and University of Patras, Greece, publications [*]

Kingston University and Wroclaw University of Technology (Poland), publications [*]

Kingston University, publications [*]

Kingston University, Publications [*]

Kingston University and University of Glasgow, Publications [*]

Supervision Team: Prof. Jean-Christophe Nebel, Dr Farzana Rahman (FS)

Supervision Team: Dr Natasha Hill (DoS), Dr Jean-Christophe Nebel

Next position: Consultant at PwC India

Supervision Team: Dr Jean-Christophe Nebel (DoS), Prof. Mansour (Lebanese-American University), Dr Souheil Khaddaj

Next position: Lecturer at Lebanese International University (Lebanon)

Supervision Team: Dr Lori Snyder (DoS), Dr Jean-Christophe Nebel, Prof. Bill Shafer

Next position: Senior Scientific Policy Officer at Food Standards Agency

Supervision Team: Dr Jean-Christophe Nebel (DoS), Prof. Barbara Pierscionek
2nd Runner-up in the video category of the Biochemical Society's Science Communication competition 2016

With 'In between the (beta) sheets'

Next position: Product and Application Consultant at Databiology

Supervision Team: Dr Jean-Christophe Nebel (DoS), Dr Dimitrios Makris, Prof. Declan Naughton

Next position: Postdoctoral Researcher in Computational Structural Biology & Associate Director of the Doctoral Training Centre at University of Oxford

Supervision Team: Dr. Hab. Eng. Malgorzata Kotulska (DoS), Dr Jean-Christophe Nebel (External advisor)
Winner of the Polish Society for Biomedical Engineering Contest for the best master thesis in the field of biomedical engineering in 2009

Next position: PhD student in Bioinformatics at Wroclaw University of Technology (Poland)

Supervision Team: Dr Jean-Christophe Nebel, Prof Robert S. H. Istepanian (DoS)

Next position: Research fellow at Kingston University

Supervision Team: Dr Jean-Christophe Nebel (DoS), Dr Darrel Greenhill, Dr Dimitrios Makris, Dr Ndedi Monekosso, Dr Malgorzata Kotulska (external - Wroclaw University of Technology, Poland)

Next position: PhD student in Bioinformatics and Computational Biophysics (2007-2011) at Wroclaw University of Technology (Poland)

Marta Fullen, Visiting Master student, 2012
Investigation of correlations between genotypes & cancers (Wroclaw Univ. Tech., Poland)
Sup. Team: J.-C. Nebel

Celine Elie, Visiting Master student, 2013
Study of crystallins refraction indices (University of Nice Sophia Antipolis, France)
Sup. Team: J.-C. Nebel, B. Pierscionek

Melanie Broutin, Visiting Master student, 2016
Bioinformatics study of crystallin aggregation (University of Nice Sophia Antipolis, France)
Sup. Team: J.-C. Nebel, B. Pierscionek

Solene Guiglion, Visiting Master student, 2017
Propeties of dimorphics interfaces (University of Nice Sophia Antipolis, France)
Sup. Team: J.-C. Nebel

Guillaume Vink, Visiting Master student, 2019
In Silico Design of Bioisosteric Modifications of a Drug for the Treatment of Diabetes (University of Nice Sophia Antipolis, France)
Sup. Team: J.-C. Nebel, S. Wren

Aaron Caffrey, PG researcher
Prediction of coil conversion to β-strand during dimerisation

Sup. Team: J.-C. Nebel

Investigation of a protein-peptide interaction which could boost the immune system when the body is attacked by microbes and viruses.
This 3D movie shows the proposed model of interaction between the two proteins (coloured in red and blue). The model is in agreement with literature findings and as such it could be used to design novel anti-microbial drugs. (see publication for details)